An HDAC6 inhibitor
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HDAC6-IN-78

Item No. 46381

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]-2-[[4-(2-fluorophenyl)-1H-1,2,3-triazol-1-yl]methyl]-pyridine
CAS Number
2509539-79-9
Synonyms
  • HDAC6 Inhibitor 78
  • Histone Deacetylase 6-IN-78
  • Histone Deacetylase 6 Inhibitor 78
Molecular Formula
C17H11F3N6O
Formula Weight
372.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
FC(F)C(O1)=NN=C1C2=CC=C(N=C2)CN3C=C(C4=C(F)C=CC=C4)N=N3
InChi Code
InChI=1S/C17H11F3N6O/c18-13-4-2-1-3-12(13)14-9-26(25-22-14)8-11-6-5-10(7-21-11)16-23-24-17(27-16)15(19)20/h1-7,9,15H,8H2
InChi Key
HRXXFMSLWLFOLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $470

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    10 mg

    $891

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    Product Description

    HDAC6-IN-78 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 24 nM).1 It is selective for HDAC6 over HDAC1-5 and HDAC7-10 (IC50s = >10,000 nM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vara Salazar, Y.I., Aldaba Arévalo, E., Bello Iglesia, T., et al. 1,3,4-Oxadiazole derivatives as histone deacetylase inhibitors. WO2020212479A1, (2020).