An antiprotozoal agent
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IID432 (trifluoroacetate salt)

Item No. 46384

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-cyano-N-[(3S)-1-(2-methyl-6-quinolinyl)-3-pyrrolidinyl]-1H-1,2,4-triazole-1-acetamide, 2,2,2-trifluoroacetate
Molecular Formula
C19H19N7O • CF3COOH
Formula Weight
475.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=NC(C=CC(N2CC[C@H](NC(CN3C=NC(C#N)=N3)=O)C2)=C4)=C4C=C1.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C19H19N7O.C2HF3O2/c1-13-2-3-14-8-16(4-5-17(14)22-13)25-7-6-15(10-25)23-19(27)11-26-12-21-18(9-20)24-26;3-2(4,5)1(6)7/h2-5,8,12,15H,6-7,10-11H2,1H3,(H,23,27);(H,6,7)/t15-;/m0./s1
InChi Key
QDKSECAMGVMUIK-RSAXXLAASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $109

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    5 mg

    $491

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    10 mg

    $927

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    25 mg

    $1,363

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    Cayman Chemical
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    Product Description

    IID432 is an antiprotozoal agent.1 It inhibits T. brucei topoisomerase II and the replication of T. cruzi in NIH3T3 cells (EC50 = 0.008 µM). IID432 (10-25 mg/kg) cures parasitemia in a mouse model of chronic T. cruzi infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. René, O., Saldivia, M., Dauphinais, M., et al. Discovery of IID432 for Chagas disease: A cyanotriazole inhibitor of Trypanosoma cruzi topoisomerase II achieves sterile cure after short-term treatment in a chronic infection model. J. Med. Chem. 69(2), 1135-1153 (2026).