A heterobifunctional molecule
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Product Type

Biochemicals

PROTAC MALT1 Degrader-1

Item No. 46386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-chloro-6-[5-[[trans-4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3 dihydro-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]cyclohexyl]methyl]-1,2,4-oxadiazol-3-yl]-3-pyridinyl]-N′-[7-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-6-yl]-urea
CAS Number
2975664-37-8
Synonyms
  • PROTAC Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1 Degrader-1
  • Proteolysis-targeting Chimera Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1 Degrader-1
  • Proteolysis-targeting Chimera MALT1 Degrader-1
Molecular Formula
C42H47ClN12O5
Formula Weight
835.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(NC1=CC(Cl)=C(C2=NOC(C[C@H]3CC[C@H](CN4CCN(C5=CC=C6C(CN(C6=O)C7CCC(NC7=O)=O)=C5)CC4)CC3)=N2)N=C1)NC8=C(C(C)C)N9N=CC=C9N=C8
InChi Code
InChI=1S/C42H47ClN12O5/c1-24(2)38-32(21-44-34-11-12-46-55(34)38)48-42(59)47-28-19-31(43)37(45-20-28)39-50-36(60-51-39)17-25-3-5-26(6-4-25)22-52-13-15-53(16-14-52)29-7-8-30-27(18-29)23-54(41(30)58)33-9-10-35(56)49-40(33)57/h7-8,11-12,18-21,24-26,33H,3-6,9-10,13-17,22-23H2,1-2H3,(H2,47,48,59)(H,49,56,57)/t25-,26-,33?
InChi Key
OJIBYXFRAXRRNV-GMTGZCRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $89

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    5 mg

    $312

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    10 mg

    $534

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    Product Description

    PROTAC MALT1 degrader-1 is a heterobifunctional molecule that contains a derivative of the mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) inhibitor MLT-985 conjugated to the cereblon (CRBN) E3 ligase ligand lenalidomide (Item No. 14643) via a linker.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, R.Y., Wang, Z.X., Zhang, M.Y., et al. MALT1 inhibitors and degraders: Strategies for NF-κB-driven malignancies. J. Med. Chem. 68(5), 5075-5096 (2025).