An aromatase inhibitor and active metabolite of LY56110
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LY43578

Item No. 46402

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,α-bis(4-chlorophenyl)-5-pyrimidinemethanol
CAS Number
26766-35-8
Synonyms
  • NSC 626916
Molecular Formula
C17H12Cl2N2O
Formula Weight
331.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
ClC1=CC=C(C(C2=CN=CN=C2)(C3=CC=C(C=C3)Cl)O)C=C1
InChi Code
InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H
InChi Key
CSRYTZCLFTYZLS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $88

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    25 mg

    $151

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    50 mg

    $248

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    Product Description

    LY43578 is a nonsteroidal aromatase inhibitor (EC50 = 0.071 µM) and an active metabolite of LY56110.1,2 Neonatal administration of LY43578 (5 mg/kg) increases ambulation and decreases the defecation rate in the open field test, decreases mounts and intromissions, and increases the lordotic quotient in adult male rats, indicating feminine-like behavior.3 However, it does not induce feminine-like behavior in adult male rats when administered on postnatal day 12.4 LY43578 increases sleep time induced by the sedative ethinamate in rats at 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, C.D., Winter, M.A., Hirsch, K.S., et al. Estrogen synthetase inhibitors. 2. Comparison of the in vitro aromatase inhibitory activity for a variety of nitrogen heterocycles substituted with diarylmethane or diarylmethanol groups. J. Med. Chem. 33(1), 416-429 (1990).

    2. Lindstrom, T.D., and Whitaker, G.W. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam. Appl. Toxicol. 8(4), 595-604 (1987).

    3. González, M.I., and Leret, M.L. Role of monoamines in the male differentiation of the brain induced by androgen aromatization. Pharmacol. Biochem. Behav. 41(4), 733-737 (1992).

    4. Gonzalez, M.I., and Leret, M.L. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol. Biochem. Behav. 47(1), 183-186 (1994).