An HNF4α antagonist and PPARγ agonist
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Isomer(s)
12031CAY10802
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BIM5078

Item No. 46433

Product Insert (PDF)
Technical Information
Formal Name
1-[(2-chloro-5-nitrophenyl)sulfonyl]-2-methyl-1H-benzimidazole
CAS Number
337506-43-1
Molecular Formula
C14H10ClN3O4S
Formula Weight
351.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
CC1=NC2=CC=CC=C2N1S(C3=C(C=CC([N+]([O-])=O)=C3)Cl)(=O)=O
InChi Code
InChI=1S/C14H10ClN3O4S/c1-9-16-12-4-2-3-5-13(12)17(9)23(21,22)14-8-10(18(19)20)6-7-11(14)15/h2-8H,1H3
InChi Key
DLUVMRPVZILBOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $85

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    10 mg

    $162

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    25 mg

    $383

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    50 mg

    $680

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    Product Description

    BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and a meta-substituted positional isomer of CAY10802 (Item No. 12031).1 It inhibits the expression of endogenous insulin mRNA in T6PNE pancreatic β-cells (IC50 = 930 nM) and induces reporter gene expression in HeLa cells expressing a peroxisome proliferator-response element (PPRE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiselyuk, A., Lee, S.H., Farber-Katz, S., et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem. Biol. 19(7), 806-818 (2012).