A synthetic intermediate
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

2-Methoxyphenyl Dihydrouracil

Item No. 46445

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methoxy-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-benzoic acid
CAS Number
2377643-33-7
Synonyms
  • 3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic Acid
Molecular Formula
C12H12N2O5
Formula Weight
264.2
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC=C(C(N2C(NC(CC2)=O)=O)=C1)OC)O
InChi Code
InChI=1S/C12H12N2O5/c1-19-9-3-2-7(11(16)17)6-8(9)14-5-4-10(15)13-12(14)18/h2-3,6H,4-5H2,1H3,(H,16,17)(H,13,15,18)
InChi Key
HCEOVKWPVMWQJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $159

    Add

    500 mg

    $254

    Add

    1 g

    $318

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    2-Methoxyphenyl dihydrouracil is a synthetic intermediate that has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) that drive the degradation of cyclin-dependent kinase 6 (Cdk6) or mixed lineage kinase domain-like protein (MLKL) and have anticancer or anti-necroptotic activity, respectively.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, W., Wen, J., Wu, Y., et al. Discovery of WWZ-11-098: A rigid and selective CDK6 degrader. Eur. J. Med. Chem. 305, 118569 (2026).

    2. Rathje, O.H., Perryman, L., Payne, R.J., et al. PROTACs targeting MLKL protect cells from necroptosis. J. Med. Chem. 66(16), 11216-11236 (2023).