A cell adhesion inhibitor
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Fuzapladib

Item No. 46447

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(ethylsulfonyl)amino]-5-(trifluoromethyl)-3-pyridinyl]-cyclohexanecarboxamide
CAS Number
141283-87-6
Synonyms
  • IKV-741
  • IS-741
Molecular Formula
C15H20F3N3O3S
Formula Weight
379.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1CCCCC1)NC2=CC(C(F)(F)F)=CN=C2NS(CC)(=O)=O
InChi Code
InChI=1S/C15H20F3N3O3S/c1-2-25(23,24)21-13-12(8-11(9-19-13)15(16,17)18)20-14(22)10-6-4-3-5-7-10/h8-10H,2-7H2,1H3,(H,19,21)(H,20,22)
InChi Key
TUWCZRFHNIOVTC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $146

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    10 mg

    $176

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    25 mg

    $390

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    Product Description

    Fuzapladib is a cell adhesion inhibitor.1 It inhibits the adhesion of HL-60 cells to human umbilical vein endothelial cells (HUVECs) stimulated by LPS or TNF-α when used at a concentration of 1 µM. Fuzapladib (0.625-20 mg/kg) reduces pancreatic hemorrhage and necrosis and increases survival in a rat model of pancreatitis.2 Fuzapladib also inhibits phospholipase A2 (PLA2; IC50 = 0.52 mM for porcine pancreatic PLA2). Formulations containing fuzapladib have been used in the treatment of acute pancreatitis in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shikama, H., Yotsuya, S., Satake, S., et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol. Pharm. Bull. 22(2), 127-131 (1999).

    2. Kimura, H., Yotsuya, S., Yuki, S., et al. Synthesis and antipancreatitis activities of novel N-(2-sulfonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives as phospholipase A2 inhibitors. Chem. Pharm. Bull. (Tokyo) 43(10), 1696-1700 (1995).