A bacterial quorum-sensing signaling molecule
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DPO

Item No. 46453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dimethyl-2(1H)-pyrazinone
CAS Number
60187-00-0
Synonyms
  • 3,5-Dimethylpyrazin-2-ol
  • 3,5-DPO
Molecular Formula
C6H8N2O
Formula Weight
124.1
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
CC1=CNC(C(C)=N1)=O
InChi Code
InChI=1S/C6H8N2O/c1-4-3-7-6(9)5(2)8-4/h3H,1-2H3,(H,7,9)
InChi Key
AJYKJVCIKQEVCF-UHFFFAOYSA-N
Origin
Bacterium/Vibrio cholerae
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    DPO is a bacterial quorum-sensing signaling molecule produced by V. cholerae, S. typhimurium, and commensal bacteria.1,2,3,4 It activates the V. cholerae transcription factor VqmA (EC50 = ~1 µM) and inhibits V. cholerae biofilm formation in vitro.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, X., Duddy, O.P., Silpe, J.E., et al. Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway. The Journal of Biological Chemisty 295(10), 2916-2931 (2020).

    2. Papenfort, K., Silpe, J.E., Schramma, K.R., et al. A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat. Chem. Biol. 13(5), 551-557 (2017).

    3. Lallement, C., Goldring, W.P.D., and Jelsbak, L. Global transcriptomic response of the AI-3 isomers 3,5-DPO and 3,6-DPO in Salmonella Typhimurium. Arch. Microbiol. 205(4), 117 (2023).

    4. Moraskie, M., Li, S., Codina, J.R., et al. DPO production by gut commensals suggests a broader role in bacterial communication and host-microbiome interactions. NPJ Biofilms Microbiomes 12(1), 19 (2025).