An inhibitor of NTPDase 3
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h-NTPDase-IN-4

Item No. 46477

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,7-bis[3,5-bis(trifluoromethyl)phenyl]-thieno[3,2-d]pyrimidine
CAS Number
2939933-09-0
Synonyms
  • Human Nucleoside Triphosphate Diphosphorylase 3-IN-4
  • Human Nucleoside Triphosphate Diphosphorylase 3 Inhibitor 4
  • h-NTPDase Inhibitor 4
Molecular Formula
C22H8F12N2S
Formula Weight
560.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
FC(F)(C1=CC(C(F)(F)F)=CC(C2=NC=NC3=C2SC=C3C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=C1)F
InChi Code
InChI=1S/C22H8F12N2S/c23-19(24,25)11-1-9(2-12(5-11)20(26,27)28)15-7-37-18-16(35-8-36-17(15)18)10-3-13(21(29,30)31)6-14(4-10)22(32,33)34/h1-8H
InChi Key
TYDAPAGFPMDHHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    5 mg

    $148

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    10 mg

    $236

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    25 mg

    $516

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    Product Description

    h-NTPDase-IN-4 is an inhibitor of nucleoside triphosphate diphosphorylase 3 (NTPDase 3; IC50 = 0.13 µM).1 It selectively inhibits NTPDase 3 over NTPDase 1 (IC50 = 3.58 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zaman, G., Ullah, S., Uzair, M., et al. Synthesis of thieno[3,2-d]pyrimidine derivatives through sequential SNAr and Suzuki reactions as selective h-NTPDase inhibitors. ChemMedChem 18(14), e202300165 (2023).