An antitubercular agent
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QST4

Item No. 46478

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(3-chlorophenyl)amino]thioxomethyl]hydrazide 8-quinolinesulfonic acid
CAS Number
2991427-35-9
Molecular Formula
C16H13ClN4O2S2
Formula Weight
392.9
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
ClC1=CC=CC(NC(NNS(C2=CC=CC3=CC=CN=C32)(=O)=O)=S)=C1
InChi Code
InChI=1S/C16H13ClN4O2S2/c17-12-6-2-7-13(10-12)19-16(24)20-21-25(22,23)14-8-1-4-11-5-3-9-18-15(11)14/h1-10,21H,(H2,19,20,24)
InChi Key
UMUSCELIFFRVEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $32

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    5 mg

    $144

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    10 mg

    $240

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    25 mg

    $480

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    Cayman Chemical
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    Product Description

    QST4 is an antitubercular agent.1 It is active against M. tuberculosis H37Rv (MIC = 6.25 µM) and M. tuberculosis clinical isolates resistant to isoniazid (Item No. 20378) and carrying inhA promoter or katG mutations (MICs = 13.05 and 21.47 µM, respectively) but not against P. aeruginosa, K. pneumoniae, or C. albicans (MICs = >500 µg/ml for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Özcan, E., Vagolu, S.K., Gündüz, M.G., et al. Novel quinoline-based thiosemicarbazide derivatives: Synthesis, DFT calculations, and investigation of antitubercular, antibacterial, and antifungal activities. ACS Omega 8(43), 40140-40152 (2023).