An inhibitor of tubulin polymerization
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Tubulin Polymerization-IN-43

Item No. 46485

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-N-(4-methoxyphenyl)-N-methyl-2-(trifluoromethyl)-4-quinazolinamine
CAS Number
2773345-90-5
Synonyms
  • Tubulin Polymerization Inhibitor 43
Molecular Formula
C17H13F4N3O
Formula Weight
351.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C3=CC=C(OC)C=C3)C)C=C1
InChi Code
InChI=1S/C17H13F4N3O/c1-24(11-4-6-12(25-2)7-5-11)15-13-9-10(18)3-8-14(13)22-16(23-15)17(19,20)21/h3-9H,1-2H3
InChi Key
YTTBMLZFUZWEBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $97

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    10 mg

    $184

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    25 mg

    $437

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    50 mg

    $631

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    Cayman Chemical
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    Product Description

    Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerization.1 It inhibits tubulin polymerization in a cell-free assay and in K562 chronic myeloid leukemia (CML) cells at 0.5 µM. Tubulin polymerization-IN-43 induces apoptosis and G2/M cell cycle arrest in K562 CML and HEL 92.1.7 erythroleukemia cells at 0.5 µM. It inhibits the proliferation of HeLa cervical cancer and HEL 92.1.7, K562, and LNCaP prostate cancer cells (IC50s = 0.011, 0.099, 0.265, and 0.377 µM, respectively) and the migration of isolated human umbilical vein endothelial cells (HUVECs) in a scratch assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, H., Wang, L.-S., Li, P., et al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur. J. Med. Chem. 256, 115470 (2023).