A synthetic intermediate
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6-Chloro-4-iodonicotinic Acid

Item No. 46499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-4-iodo-3-pyridinecarboxylic acid
CAS Number
1211578-80-1
Molecular Formula
C6H3ClINO2
Formula Weight
283.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS, pH 7.2: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CN=C(C=C1I)Cl)O
InChi Code
InChI=1S/C6H3ClINO2/c7-5-1-4(8)3(2-9-5)6(10)11/h1-2H,(H,10,11)
InChi Key
QFFFXLLUGUHIHH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $25

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    100 mg

    $48

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    500 mg

    $200

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    1 g

    $350

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    Product Description

    6-Chloro-4-iodonicotinic acid is a synthetic intermediate.1 It has been used in the synthesis of an inhibitor of the ATPase activity of DNA polymerase θ.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mochirian, P., Papp, R., Mathieu, M.C., et al. The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor. J. Med. Chem. 68(18), 19726-19745 (2025).