An inhibitor of RNA polymerase I-mediated transcription
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BMH-22

Item No. 46502

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4,7,9-tetramethyl-benzo[b][1,8]naphthyridin-5-amine
CAS Number
309726-06-5
Molecular Formula
C16H17N3
Formula Weight
251.3
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
NC1=C2C=C(C)C=C(C)C2=NC3=NC(C)=CC(C)=C31
InChi Code
InChI=1S/C16H17N3/c1-8-5-10(3)15-12(6-8)14(17)13-9(2)7-11(4)18-16(13)19-15/h5-7H,1-4H3,(H2,17,18,19)
InChi Key
ZNPSDSMZKLWRLO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $90

    Add

    10 mg

    $135

    Add

    25 mg

    $225

    Add

    50 mg

    $405

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    BMH-22 is an inhibitor of RNA polymerase I-mediated transcription and an inducer of RNA polymerase I transcription stress.1 It inhibits nascent rRNA synthesis and reduces the expression of the 45S rRNA precursor in A375 melanoma cells at 10 µM. It also induces segregation of the nucleolus in p53-null Saos-2 osteosarcoma cells and destabilizes the RNA polymerase I subunit RPA194 in a proteasome-dependent manner in A375 cells. BMH-22 reduces the proliferation of HCT116 cells in a p53-independent manner but stabilizes p53 in A375 cells.1,2 It induces cell cycle arrest at the G2/M phase in BC3 B cell lymphoma cells and reduces tumor growth in an orthotopic BC3 mouse xenograft model at 20 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peltonen, K., Colis, L., Liu, H., et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol. Cancer Ther. 13(11), 2537-2546 (2014).

    2. Peltonen, K., Colis, L., Liu, H., et al. Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS One 5(9), e12996 (2010).