A p18INK4C inhibitor
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P18IN003

Item No. 46505

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-4,5-bis(4-methoxyphenyl)-2H-imidazol-2-one
CAS Number
71727-40-7
Molecular Formula
C17H16N2O3
Formula Weight
296.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(C=C3)OC)N1
InChi Code
InChI=1S/C17H16N2O3/c1-21-13-7-3-11(4-8-13)15-16(19-17(20)18-15)12-5-9-14(22-2)10-6-12/h3-10H,1-2H3,(H2,18,19,20)
InChi Key
JOTSGKDUQMLZLE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $88

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    10 mg

    $167

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    25 mg

    $330

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    50 mg

    $440

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    Cayman Chemical
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    Product Description

    P18IN003 is an inhibitor of p18INK4C.1 It increases the number of cobblestone islands in long-term cultures of isolated mouse bone marrow nucleated cells (BMNCs), indicating an increase in the frequency of primitive hematopoietic cells, in a p18INK4C-dependent manner. P18IN003 (20 nM) sensitizes p16highpRbhigh patient-derived breast cancer cells to the cyclin-dependent kinase 4 (Cdk4) and Cdk6 inhibitor ribociclib (LEE011; Item No. 17666).2 It has been used to promote the expansion of hematopoietic cells in vitro prior to competitive bone marrow transplant in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, Y., Yang, P., Shen, H., et al. Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic stem cells. Nat. Commun. 6, 6328 (2015).

    2. Palafox, M., Monserrat, L., Bellet, M., et al. Author correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer. Nat. Commun. 13(1), 6928 (2022).