An inhibitor of the claudin-1-c-Src protein-protein interaction
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PDS-0330

Item No. 46524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[[4-(2-benzoxazolyl)phenyl]amino]thioxomethyl]-2-naphthalenecarboxamide
CAS Number
2904682-19-3
Synonyms
  • KVA-E-23A
Molecular Formula
C25H17N3O2S
Formula Weight
423.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC2=C(C=CC=C2)C=C1)NC(NC3=CC=C(C4=NC5=C(O4)C=CC=C5)C=C3)=S
InChi Code
InChI=1S/C25H17N3O2S/c29-23(19-10-9-16-5-1-2-6-18(16)15-19)28-25(31)26-20-13-11-17(12-14-20)24-27-21-7-3-4-8-22(21)30-24/h1-15H,(H2,26,28,29,31)
InChi Key
DRGVVUJKZXEUFA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $139

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    10 mg

    $222

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    25 mg

    $417

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    50 mg

    $765

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    Cayman Chemical
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    Product Description

    PDS-0330 is an inhibitor of the protein-protein interaction between claudin-1 and c-Src.1 It binds to claudin-1 (Kd = 22.9 µM) and reduces the levels of phosphorylated c-Src and Akt in SW620 colorectal cancer cells. PDS-0330 decreases the viability of SW620 cells, which endogenously overexpress claudin-1, but not of HCT116 colorectal cancer cells, which do not express claudin-1 (EC50s = 9.4 and 95 µM, respectively). It induces apoptosis in, and inhibits the migration of, SW620 cells. PDS-0330 (5-10 mg/kg) increases intratumoral apoptosis and reduces tumor volume in a SW620 mouse xenograft model and in patient-derived xenograft (PDX) mouse model of chemotherapy-resistant colon cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fatima, I., Uppada, J.P., Chhonker, Y.S., et al. Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomed. Pharmacother. 159, 114255 (2023).