Host: E. coli • AA: 117-269
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Interleukin-1β (human, recombinant)

Item No. 46538

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Catabolin
  • IL-1F2
Purity
≥90% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg, as determined by the LAL endotoxin assay
Source
Recombinant human IL-1β expressed in E. coli
Amino Acids
117-269
MW
17.5 kDa
Formulation (Request formulation change)
50 mM Tris-HCl, pH 7.5, with 200 mM sodium chloride, 20% glycerol, and 1 mM DTT
UniProt Accession №
P01584
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $1,229

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    Product Description

    Interleukin-1β (IL-1β) is a cytokine and member of the IL-1 family of proteins.1 It is produced as an inactive cytosolic pro-cytokine, which is cleaved by caspase-1 into mature IL-1β.2 IL-1β is found primarily in mononuclear cells where it can be secreted by immune cells during pyroptosis via the NOD-like receptor protein 3 (NLRP3) inflammasome pathway following its activation by bacterial and viral pathogens.3,4 IL-1β binds to IL-1 receptor 1 (IL-1R1), which is expressed in a variety of cells, including T cells, fibroblasts, and keratinocytes, and IL-1R2, which is expressed primarily in B cells and neutrophils with IL-1R3 as a co-receptor.2,5 Upon binding to its receptors, IL-1β induces kinase signaling cascades leading to the induction of NF-κB transcriptional activity and modulation of immune and inflammatory responses.1,2,6 IL-1β activity can be inhibited by the endogenous protein IL-1R antagonist (IL-1Ra), which inhibits IL-1β binding by preventing IL-1R1 interaction with its co-receptor IL-1R3.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dinarello, C.A. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol. Rev. 281(1), 8-27 (2018).

    2. Migliorini, P., Italiani, P., Pratesi, F., et al. The IL-1 family cytokines and receptors in autoimmune diseases. Autoimmun. Rev. 19(9), 102617 (2020).

    3. Sollberger, G., Strittmatter, G.E., Garstkiewicz, M., et al. Caspase-I: The inflammasome and beyond. Innate Immun. 20(2), 115-125 (2014).

    4. Abdul-Sater, A.A., Saïd-Sadier, N., Ojcius, D.M., et al. Inflammasomes bridge signalling between pathogen identification and the immune response. Drugs Today (Barc). 45(Suppl. B), 105-112 (2009).

    5. Suyama, Y., Kubota, Y., Ninomiya, T., et al. Immunohistochemical analysis of interleukin-1a, its type I receptor and antagonist in keratocystic odontogenic tumors. J. Oral Pathol. Med. 37(9), 560-564 (2008).

    6. Sun, Z., and Andersson, R. NF-kB activation and inhibition: A review. Shock 18(2), 99-106 (2002).