A calpain inhibitor
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SNJ-1945

Item No. 46557

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-[[[(1S)-3-(cyclopropylamino)-2,3-dioxo-1-(phenylmethyl)propyl]amino]carbonyl]-3-methylbutyl]-carbamic acid, 2-(2 methoxyethoxy)ethyl ester
CAS Number
854402-59-8
Synonyms
  • Mitucapistat
Molecular Formula
C25H37N3O7
Formula Weight
491.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(NC1CC1)C([C@H](CC2=CC=CC=C2)NC([C@H](CC(C)C)NC(OCCOCCOC)=O)=O)=O
InChi Code
InChI=1S/C25H37N3O7/c1-17(2)15-21(28-25(32)35-14-13-34-12-11-33-3)23(30)27-20(16-18-7-5-4-6-8-18)22(29)24(31)26-19-9-10-19/h4-8,17,19-21H,9-16H2,1-3H3,(H,26,31)(H,27,30)(H,28,32)/t20-,21-/m0/s1
InChi Key
PMEQLUMDXFJNRY-SFTDATJTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $139

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    25 mg

    $297

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    Product Description

    SNJ-1945 is a calpain inhibitor (IC50s = 0.17 and 0.099 µM for µ-calpain/calpain-1 and m-calpain/calpain-2, respectively).1 It inhibits proteolysis of the calpain substrate α-spectrin in rat, monkey, and human retinal soluble protein preparations at 100 µM.2 Oral administration of SNJ-1945 (120 and 240 mg/kg) reduces retinal degeneration in a rat model of ocular hypertension. It reduces COX-2 and caspase-1 levels and increases viability in SH-SY5Y cell models of experimental parkinsonism at 100 and 250 µM.3 It also reduces the generation of reactive oxygen species (ROS) in SH-SY5Y cells in an in vitro parkinsonism model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shirasaki, Y., Miyashita, H., Yamaguchi, M., et al. Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site. Bioorg. Med. Chem. 13(14), 4473-4484 (2005).

    2. Oka, T., Walkup, R.D., Tamada, Y., et al. Amelioration of retinal degeneration and proteolysis in acute ocular hypertensive rats by calpain inhibitor ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester. Neuroscience 141(4), 2139-2145 (2006).

    3. Knaryan, V.H., Samantaray, S., Park, S., et al. SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP+ and rotenone. J. Neurochem. 130(2), 280-290 (2014).