An MRP1 inhibitor
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Reversan

Item No. 46558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS Number
313397-13-6
Synonyms
  • CBLC4H10
Molecular Formula
C26H27N5O2
Formula Weight
441.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCCCN1CCOCC1)C2=C3N=C(C=C(N3N=C2)C4=CC=CC=C4)C5=CC=CC=C5
InChi Code
InChI=1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32)
InChi Key
JTRXWCLQFAZHGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $149

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    25 mg

    $248

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    50 mg

    $396

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    Cayman Chemical
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    Product Description

    Reversan is an inhibitor of multidrug resistance-associated protein 1 (MRP1).1 It sensitizes MCF-7/VP breast cancer cells, which have amplified MRP1 and low P-glycoprotein/MDR1 expression, to the MRP1 substrates doxorubicin (Item No. 15007), vincristine (Item No. 11764), and etoposide (Item No. 12092) by 3.8-, 8.9-, and 2.7-fold, respectively, at 5 µM but does not sensitize these cells to the non-MRP1 substrates cisplatin (Item No. 13119) or paclitaxel (Item No. 10461) at 5 µM. Reversan (10 mg/kg) enhances vincristine- or etoposide-induced increases in survival in a model of neuroblastoma using hMYCN transgenic mice. It restores the alveolar fluid clearance rate and decreases bacterial colony-forming units (CFUs) in the injured lobe in ex vivo perfused human lungs injured with E. coli pneumonia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burkhart, C.A., Watt, F., Murray, J., et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69(16), 6573-6580 (2009).

    2. He, H., Sugita, S., Hao, Q., et al. Potential role of extracellular vesicles in bacterial phagocytosis during Escherichia coli pneumonia in ex vivo perfused human lungs. Intensive Care Med. Exp. 14(1), 56 (2026).