An inhibitor of calpain-1, calpain-2, and calpain-9
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Dazcapistat

Item No. 46569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-amino-2,3-dioxo-1-(phenylmethyl)propyl]-4-(2-fluorophenyl)-2-methyl-5-oxazolecarboxamide
CAS Number
2221010-42-8
Synonyms
  • BLD-2660
Molecular Formula
C21H18FN3O4
Formula Weight
395.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C(C(CC1=CC=CC=C1)NC(C2=C(N=C(O2)C)C3=C(C=CC=C3)F)=O)=O)N
InChi Code
InChI=1S/C21H18FN3O4/c1-12-24-17(14-9-5-6-10-15(14)22)19(29-12)21(28)25-16(18(26)20(23)27)11-13-7-3-2-4-8-13/h2-10,16H,11H2,1H3,(H2,23,27)(H,25,28)
InChi Key
XYQHCMDVGIJOTA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $89

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    10 mg

    $151

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    25 mg

    $289

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    50 mg

    $490

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    Product Description

    Dazcapistat is an inhibitor of calpain-1, calpain-2, and calpain-9 (IC50s = <3 µM for all).1 It inhibits calpain activity in SH-SY5Y cells (IC50 = 10-25 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yuan, S., Adler, M., Emayan, K., et al. Calpain modulators and therapeutic uses thereof background. (2018).