A building block
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(E)-3-Iodoacrylic Acid

Item No. 46573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-iodo-2E-propenoic acid
CAS Number
6372-02-7
Synonyms
  • trans-3-Iodoacrylic Acid
  • (E)-3-Iodoprop-2-enoic Acid
Molecular Formula
C3H3IO2
Formula Weight
198.0
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
I/C=C/C(O)=O
InChi Code
InChI=1S/C3H3IO2/c4-2-1-3(5)6/h1-2H,(H,5,6)/b2-1+
InChi Key
IBFDLVHJHUMSAC-OWOJBTEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $99

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    500 mg

    $178

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    1 g

    $238

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    5 g

    $693

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    Product Description

    (E)-3-Iodoacrylic acid is a building block.1,2,3 It has been used in the synthesis of cathepsin L inhibitors and a histone deacetylase (HDAC) inhibitor, as well as in the total synthesis of the marine secondary metabolite cylindramide.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández-de-la-Pradilla, A., Quílez, C., Uršič, T., et al. Peptidyl keto vinyl amides as improved inhibitors of cathepsin L. Bioorg. Med. Chem. 137:118609, (2026).

    2. Shen, J., Woodward, R., Kedenburg, J.P., et al. Histone deacetylase inhibitors through click chemistry. J. Med. Chem. 51(23), 7417-7427 (2008).

    3. Cramer, N., Laschat, S., Baro, A., et al. Enantioselective total synthesis of cylindramide. Angew. Chem. Int. Ed. Engl. 44(5), 820-822 (2005).