A nucleoside sugar
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Product Categories

Product Type

Biochemicals
Nucleotides/Nucleosides

Guanosine 5′-diphospho-D-mannose (sodium salt)

Item No. 46575

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
guanosine 5′-(trihydrogen diphosphate), P′-D-mannopyranosyl ester, disodium salt
CAS Number
103301-73-1
Synonyms
  • GDP-mannose
  • GDP-D-mannose
Molecular Formula
C16H23N5O16P2 • 2Na
Formula Weight
649.3
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O[C@H]1[C@@H](O[C@@H]([C@H]1O)COP(OP(OC2[C@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)([O-])=O)([O-])=O)N3C=NC4=C3NC(N)=NC4=O.[Na+].[Na+]
InChi Code
InChI=1S/C16H25N5O16P2.2Na/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15;;/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28);;/q;2*+1/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15?;;/m1../s1
InChi Key
XOAGKSFNHBWACO-NJLPRVPTSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $85

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    10 mg

    $128

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    25 mg

    $276

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    50 mg

    $383

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    Product Description

    Guanosine 5’-diphospho-D-mannose is a nucleoside sugar and substrate for GDP-D-mannose-4,6-dehydratase (GMD), the first enzyme in GDP-β-L-fucose (Item No. 46188) biosynthesis.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bisso, A., Sturla, L., Zanardi, D., et al. Structural and enzymatic characterization of human recombinant GDP-ᴅ-mannose-4,6-dehydratase. FEBS Lett. 456(3), 370-374 (1999).

    2. Somoza, J.R., Menon, S., Schmidt, H., et al. Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose. Structure 8(2), 123-135 (2000).