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pGk13a is a membrane-labeling probe.1 It contains palmitic acid (Item Nos. 10006627 | 43561), which acts as a membrane anchor, conjugated to a poly-D-lysine peptide, which acts as a hydrogel anchor during chemical softening, and an azide group that can be conjugated to fluorophores via click chemistry. It has been used in ultrastructural membrane expansion microscopy (umExM) to increase the resolution of confocal microscopy to approximately 60 nm, allowing for the visualization of membranous structures, proteins, and RNA, segmentation of neuronal compartments, and tracing of axons in mouse brain slices.
WARNING This product is not for human or veterinary use.
1. Dense, continuous membrane labeling and expansion microscopy visualization of ultrastructure in tissues. Nat. Commun. 16(1), 1579 (2025).