A motilin receptor agonist
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Camicinal

Item No. 46664

Technical Information
Formal Name
1-[4-[(3-fluorophenyl)amino]-1-piperidinyl]-2-[4-[[(3S)-3-methyl-1-piperazinyl]methyl]phenyl]-ethanone
CAS Number
923565-21-3
Synonyms
  • GSK962040
Molecular Formula
C25H33FN4O
Formula Weight
Purity
≥98%
Formulation
A solid
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
C[C@H](NCC1)CN1CC(C=C2)=CC=C2CC(N3CCC(CC3)NC4=CC(F)=CC=C4)=O
InChi Code
InChI=1S/C25H33FN4O/c1-19-17-29(14-11-27-19)18-21-7-5-20(6-8-21)15-25(31)30-12-9-23(10-13-30)28-24-4-2-3-22(26)16-24/h2-8,16,19,23,27-28H,9-15,17-18H2,1H3/t19-/m0/s1
InChi Key
RZKDEGZIFSJVNA-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Camicinal is a motilin receptor agonist.1 It increases intracellular calcium levels in CHO-K1 cells expressing the human motilin receptor (EC50 =12.59 nM). Camicinal potentiates electrical field-stimulated contractions in isolated rabbit gastric antrum strips by at 0.3-3 µM and acetylcholine-induced contractions in ex vivo isolated human gastric strips at 10 µM.1,2 It increases excreted fecal weight in rabbits at 5 mg/kg.

    WARNING This product is not for human or veterinary use.