An anticancer agent
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CU-242

Item No. 46669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-8-quinolinyl-benzenesulfonamide
CAS Number
16082-64-7
Synonyms
  • 2-Amino-N-quinoline-8-yl-benzenesulfonamide
  • NUN82647
  • QBS
Molecular Formula
C15H13N3O2S
Formula Weight
299.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=S(NC1=CC=CC2=CC=CN=C21)(C3=C(N)C=CC=C3)=O
InChi Code
InChI=1S/C15H13N3O2S/c16-12-7-1-2-9-14(12)21(19,20)18-13-8-3-5-11-6-4-10-17-15(11)13/h1-10,18H,16H2
InChi Key
NIOOKXAMJQVDGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $322

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    50 mg

    $446

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    Cayman Chemical
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    Product Description

    CU-242 is an anticancer agent.1,2 It induces cytotoxicity in Jurkat and MOLT-4 lymphoblastic leukemia cells and Raji and Ramos (RA 1) Burkitt lymphoma cells (EC50s = 0.77, 0.87, 1.26, and 0.96 µM, respectively) and induces apoptosis and cell cycle arrest at the G2/M phase in Jurkat cells.1 CU-242 induces stabilization of IκBα (EC50 = 11 µM) and inhibits nuclear translocation of NF-κB (IC50 = 2 µM) in reporter assays.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, Y.-H., Shin, K.-J., Lee, T.G., et al. G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem. Pharmacol. 69(9), 1333-1341 (2005).

    2. Xie, Y., Deng, S., Thomas, C.J., et al. Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activation. Bioorg. Med. Chem. Lett. 18(1), 329-335 (2008).