An inhibitor of PTP1B and TCPTP
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Alternative(s)
40169ABBV-CLS-484 (hydrochloride)
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ABBV-CLS-484

Item No. 46979

Product Insert (PDF)
Technical Information
Formal Name
5-[(7R)-1-fluoro-5,6,7,8-tetrahydro-3-hydroxy-7-[(3-methylbutyl)amino]-2-naphthalenyl]-1,2,5-thiadiazolidin-3-one, 1,1-dioxide
CAS Number
2489404-97-7
Synonyms
  • Osunprotafib
Molecular Formula
C17H24FN3O4S
Formula Weight
385.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly Soluble: 1-10 mg/mlDMSO: Sparingly Soluble: 1-10 mg/mlWater: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(NS1(=O)=O)CN1C2=C(O)C=C3CC[C@H](CC3=C2F)NCCC(C)C
InChi Code
InChI=1S/C17H24FN3O4S/c1-10(2)5-6-19-12-4-3-11-7-14(22)17(16(18)13(11)8-12)21-9-15(23)20-26(21,24)25/h7,10,12,19,22H,3-6,8-9H2,1-2H3,(H,20,23)/t12-/m1/s1
InChi Key
DVFCRTGTEXUFIN-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $539

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    5 mg

    $1,617

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    10 mg

    $2,426

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    Cayman Chemical
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    Product Description

    An inhibitor of PTP1B and TCPTP (IC50s = 2.5 and 1.8 nM, respectively); selective for PTP1B and TCPTP over PTP1C and PTP2C (IC50s = >10 µM for both) but does inhibit MEG2 (IC50 = 15 nM); has anticancer activity in vitro; has anticancer activity in mice in combination with an anti-PD-1 antibody

    WARNING This product is not for human or veterinary use.