For the quantification of 2’3’-cGAMP in cell lysates, plasma, serum, and tissue samples
Features
  • Measure 2'3'-cGAMP in cell lysates, plasma, serum, and tissue samples
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Lower limit of detection (LLOD) is 9.6 pg/ml (0.01 pmol/ml)
  • Run overnight or incubate for just 2 hours without compromising sensitivity
  • Monitor the kinetics of 2'3'-cGAMP formation and hydrolysis in a biological setting
  • Identify compounds that modulate cGAS activity by monitoring cGAMP levels
  • View the scientific poster: Development and Validation of a 2’3’-cGAMP ELISA
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2'3'-cGAMP ELISA Kit

Item No. 501700

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • 2'3'-cGAMP EIA Kit
  • 2'3'-Cyclic GMP-AMP
  • Guanosine-Adenosine 2',3'-cyclic monophosphate
Limit of Detection
9.6 pg/ml (14.2 pM)
Assay Range
6.1 pg/ml-100 ng/ml (9 pM-148.3 nM)
Sensitivity
73 pg/ml (108 pM)
License
This product was developed in conjunction with BIOLOG Life Science Institute.
Origin
Animal/Bovine, Animal/Rabbit
Shipping & Storage Information
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
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    96 solid wells

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    96 strip wells

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    Product Description

    Cayman’s 2’3’-cGAMP ELISA Kit is a competitive assay that can be used for quantification of 2’3’-cGAMP in cell lysates, plasma, serum, and tissue samples. This assay has a range of 6.1 pg/ml - 100 ng/ml (9 pM - 148.3 nM), with a midpoint (50% B/B0) of approximately 900 pg/ml (1,335 pM), and a sensitivity (80% B/B0) of approximately 85 pg/ml (126 pM). Powered by BIOLOG Life Science Institute

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Fréreux, C., Karam, J.A.Q., Howley, B.V., et al. PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development. Commun. Biol. 9(1), 179 (2026).

    Fréreux, C., and Howe, P.H. ELISA-based enzyme kinetics assay for measuring cGAS activity. Bio. Protoc. 16(7), e5655 (2026).

    Chen, M., Li, Y., Zhu, J.-Y., et al. Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling. Cell Rep. 44(2), 115251 (2025).

    Hao, X., Zhao, B., Towers, M., et al. TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation. Nat. Aging 4(2), 185-197 (2024).

    Sun, H., Huang, Y., Mei, S., et al. A nuclear export signal is required for cGAS to sense cytosolic DNA. Cell Rep. 34(1), 108586 (2021).

    Yu, C.-H., Davidson, S., Harapas, C.R., et al. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Cell 183(3), 636-649 (2020).

    Pathare, G.R., Decout, A., Glück, S., et al. Structural mechanism of cGAS inhibition by the nucleosome. Nature (2020).

    Ning, L., Wei, W., Wenyang, J., et al. Cytosolic DNA-STING-NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide. Clin. Transl. Med. 10(7), e228 (2020).

    Zhou, C., Chen, X., Planells-Cases, R., et al. Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity. Immunity 52(5), 767-781 (2020).

    Maekawa, H., Inoue, T., Ouchi, H., et al. Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury. Cell Rep. 29(5), 1261-1273 (2019).