An immunometric assay for the quantification of intact mertansine-human IgG in biological fluids and cell culture supernatants
Features
  • ​Used for the quantitative determination of intact antibody-mertansine conjugate levels
  • Validated in mouse, rat, rabbit, pig and monkey sera, and cell culture supernatants
  • Rapid turnaround time (typically 4-4.5 hours for complete assay)
  • Can be used for pharmacokinetic and pharmacodynamic studies, ADC stability assessment during development, and quality control in manufacturing processes
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Product Categories

Product Type

Assay & Reagent Kits
Assay Kits
ELISA

Research Area

Cancer
Cell Cycle
Cell Death
Immunology

Application

ELISA

Human Therapeutic IgG Mertansine ADC ELISA Kit

Item No. 502872

Kit Booklet (PDF)Validation Data (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • DM1
  • Emtansine
Limit of Detection
0.2 ng/ml
Assay Range
0.47-30 ng/ml
Origin
Animal/Bovine, Animal/Goat, Animal/Rabbit, Recombinant antibody produced in CHO cells
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $750

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    Cayman Chemical
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    Product Description

    Cayman’s Human Therapeutic IgG Mertansine ADC ELISA Kit is an immunometric (i.e. sandwich) assay that can be used for the quantification of mertansine-human IgG complexes (mertansine ADCs) in mouse, rat, rabbit, and non-human primate serum and cell culture supernatant. The standard curve spans the range of 0.47-30 ng/ml, with a lower limit of detection (LLOD) of 0.2 ng/ml.

    Please note that the standard included in this kit consists of mertansine conjugated to a recombinant humanized IgG1 monoclonal antibody and is suitable for semi-quantitative analysis. For fully quantitative results, users should generate a standard curve using their own sample-specific mertansine-conjugated antibody, ensuring the dose range matches the kit’s provided standard.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.