LipidLaunch™ LNP Screening Set (Loadable)

Lipid nanoparticles (LNPs) are a subset of lipid-based drug delivery (LBDD) systems that utilize ionizable cationic lipids, such as ALC-0315, C14-4, DLin-MC3-DMA (MC3), (S)-C12-200, and SM-102, for the delivery of nucleic acid payloads to cells.^1,2 LNPs are typically composed of four types of lipids: a cationic or ionizable cationic lipid, a helper phospholipid, a PEGylated lipid, and cholesterol. Release of LNP cargo into target cells is heavily influenced by the ionizable cationic lipid component, which undergoes protonation in the acidic environment of the endosomes, resulting in membrane disruption and release of cargo into the cell.³ The ionizable cationic aminolipids in this kit have been used in combination with other lipids in the formation of LNPs for the delivery of various cargo in vitro and in vivo. Cayman’s LipidLaunch™ LNP Screening Set (Loadable) uses the ionizable cationic aminolipids to facilitate efficient payload delivery in research models with reduced toxicity compared to traditional methods.

WARNING This product is not for human or veterinary use.

1. Mitchell, M.J., Billingsley, M.M., Haley, R.M., et al. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20(2), 101-124 (2021).

2. Viegas, C., Patrício, A.B., Prata, J.M., et al. Solid lipid nanoparticles vs. nanostructured lipid carriers: A comparative review. Pharmaceutics 15, 1593 (2023).

3. Han, X., Zhang, H., Butowska, K., et al. An ionizable lipid toolbox for RNA delivery. Nat. Commun. 12, 7233 (2021).