A competitive assay that can be used for quantification of PGD2
Features
  • Measure PGD2 in multiple sample types
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Measure PGD2 levels down to 55 pg/ml
  • Incubation: 18 hours | Development: 90-120 minutes | Read: Colorimetric at 405-420 nm
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Prostaglandin D2 ELISA Kit

Item No. 512031

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • PGD2 EIA Kit
Assay Range
19.5-2,500 pg/ml
Sensitivity
80% B/B0: 55 pg/ml
Cross Reactivity
(Prostaglandin D2) 100%(Prostaglandin F2α) 92.4%(Prostaglandin J2) 21.6%(Prostaglandin E2) 2.86%(Thromboxane B2) 2.54%(11β-Prostaglandin F2α) 1.99%(8-iso Prostaglandin F2α) 1.90%(Prostaglandin A2) 0.72%(12(S)-HHTrE) 0.16%(6-keto Prostaglandin F1α) 0.05%(13,14-dihydro-15-keto Prostaglandin D2) 0.02%(Arachidonic Acid) <0.01%(Leukotriene D4) <0.01%(tetranor-PGDM) <0.01%(tetranor-PGEM) <0.01%(tetranor-PGFM) <0.01%(tetranor-PGJM) <0.01%
Origin
Animal/Bovine, Animal/Eel, Animal/Goat, Animal/Mouse
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    Product Description

    Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kDa glutathione-independent lipocalin-type PGD2 synthase. This PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized in mast cells and leukocytes by a cellular, myeloid-type, glutathione-dependent PGD synthase. This PGD2 which is formed in the intracellular and vascular compartments is rapidly metabolized to 11β-PGF2α and other metabolites. Measurement of the parent eicosanoid PGD2 is appropriate in cell culture lysates and in CSF, where concentrations of several hundred pg/ml have been measured. Cayman’s PGD2 ELISA Kit is a competitive assay that can be used for quantification of PGD2 in cell culture lysates and enzymatic reactions.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Gan, P.X.L., Liao, W., Lim, H.F., et al. Dexamethasone protects against Aspergillus fumigatus-induced severe asthma via modulating pulmonary immunometabolism. Pharmacol. Res. 196, 106929 (2023).

    Ualiyeva, S., Lemire, E., Aviles, E.C., et al. Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Sci. Immunol. 6(66), eabj0474 (2021).

    Xie, G., Zhou, Y., Zheng, Q., et al. Association between phthalate exposure and reproductive health in patients undergoing assisted reproductive treatment: A systematic review and meta-analysis. Reproductive Toxicology 136, 108948 (2025).

    Yoo, J.-M., Yang, J.-H., Kim, Y.S., et al. Inhibitory effect of Loranthus parasiticus on IgE-mediated allergic responses in RBL-2H3 cells. Mediators Inflamm. 2016, 8742562 (2016).

    Gomez-Abellan, V., Montero, J., Lopez-Munoz, A., et al. Professional phagocytic granulocyte-derived PGD2 regulates the rsolution of inflammation in fish. Develop. Comp. Immunol. 52(2), 182-191 (2015).

    Malaviya, A., and Sylvester, P.W. Synergistic antiproliferative effects of combined g-tocotrienol and PPARg antagonist treatment are mediated through PPARg-independent mechanisms in breast cancer cells. PPAR Res. 2014(439146), (2014).

    Sun, Y., Jia, Z., Liu, G., et al. PPARγ agonist rosiglitazone suppresses renal mPGES-1/PGE2 pathway in db/db mice. PPAR Res. 2013:e612971, (2013).