A competitive assay that can be used for quantification of 2-methoxyestradiol in plasma, urine, and other sample matrices
Features
  • Detect 2-ME2
  • Assay 24 samples in triplicate or 36 samples in duplicate
  • Measure 2-ME2 levels down to 40 pg/ml
  • Incubation: 18 hours | Development: 90-120 minutes | Read: Colorimetric at 405-420 nm
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2-Methoxyestradiol ELISA Kit

Item No. 582261

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • 2-Hydroxyestradiol 2-methyl ester
  • 2-ME2 EIA Kit
Assay Range
13.1-8,000 pg/ml
Sensitivity
80% B/B0: 40 pg/ml
Cross Reactivity
(2-Methoxyestradiol) 100%(Estradiol) 0.29%(Estrone) 0.04%(Progesterone) 0.04%(Testosterone) 0.02%(Androstenolone) 0.01%(Estriol) 0.01%(Cholesterol) <0.01%(17α-Estradiol) <0.01%(Pregnenolone) <0.01%
Origin
Animal/Bovine, Animal/Eel, Animal/Mouse, Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    96 solid wells

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    Bioanalysis & Assay Development Services
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    Product Description

    2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol produced by CYP450-dependant hydroxylation followed by catechol-O-methyltransferase-catalyzed O-methylation. Deficiency in catechol-O-methyltransferase is associated with pre-eclampsia. Therefore, 2-ME2 may be utilized as a plasma and urinary diagnostic marker for this disease, as well as a therapeutic supplement for its prevention. Several clinical trials have demonstrated the antitumor effects of 2-ME2 in prostate cancer, breast cancer, renal cell carcinoma, ovarian cancer, glioblastoma, and multiple myeloma. Other studies indicate that 2-ME2 exhibits more potent cardioprotective effects than estradiol. Cayman’s 2-Methoxyestradiol ELISA Kit is a competitive assay that can be used for quantification of 2-ME2 in plasma, urine, and other sample matrices.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.