For the measurement of the growth regulatory hormone N-Acetyl Ser-Asp-Lys-Pro (AcSDKP)
Features
  • Measure AcSDKP in mammalian plasma and urine samples
  • Assay 33 samples in duplicate
  • Incubation: Overnight
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AcSDKP EIA Kit

Item No. 589451

Kit Booklet (PDF)
Technical Information
Synonyms
  • N-Acetyl Ser-Asp-Lys-Pro ELISA Kit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $1,080

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    Precellys
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    Product Description

    N-Acetyl Ser-Asp-Lys-Pro (AcSDKP) is a tetrapeptide growth regulatory hormone which inhibits the proliferation of hematopoietic stem cells.1 The dipeptidase Angiotensin Converting Enzyme (ACE) actively metabolizes circulating AcSDKP, giving it a brief plasma half life of 4 to 5 minutes. ACE inhibition is a major therapeutic end point in the treatment of hypertension management. A further consequence of ACE inhibition is the accumulation of AcSDKP in the plasma and the urine.2,3 This accumulation may have physiological effects, which are manifested as the anemia of chronic ACE inhibitor toxicity. More commonly, plasma and urine AcSDKP levels can be used as a biomarker of ACE inhibition and an index of patient compliance with therapy.4 Measurement of AcSDKP in human urine or plasma can be readily accomplished by enzyme immunoassay.5 [Bertin Catalog No. A05881]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lenfant, M., Wdzieczak-Bakala, J., Guittet, E., et al. Inhibitor of hematopoietic pluripotent stem cell proliferation: Purification and determination of its structure. Proc. Natl. Acad. Sci. USA 86, 779-782 (1989).

    2. Azizi, M., Ezan, E., Nicolet, L., et al. High plasma level of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline: A new marker of chronic angiotensin-converting enzyme inhibition. Hypertension 30(5), 1015-1019 (1997).

    3. Azizi, M., Ezan, E., Reny, J.L., et al. Renal and metabolic clearance of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (AcSDKP) during angiotension-converting enzyme inhibition in humans. Hypertension 33(3), 879-886 (1999).

    4. Struthers, A.D., MacFadyen, R., Fraser, C., et al. Nonadherence with angiotensin-converting enzyme inhibitor therapy. A comparison of different ways of measuring it in patients with chronic heart failure. J. Am. Coll. Cardiol. 34(7), 2072-2077 (1999).

    5. Pradelles, P., Frobert, Y., Créminon, C., et al. Negative regulator of pluripotent hematopoietic stem cell proliferation in human white blood cells and plasma as analysed by enzyme immunoassay. Biochem. Biophys. Res. Commun. 170, 986-993 (1990).