EP₂ Receptor (human) Reporter Assay Kit

Prostaglandin E₂ (PGE₂) is one of the most important biologically active prostanoids which exerts its actions mainly by binding to four distinct E-type prostanoid receptors: EP₁, EP₂, EP₃, and EP₄. These four G protein-coupled receptors (GPCRs) exhibit differences in signal transduction mechanisms, tissue localization, and regulation of expression. EP₂ receptors are expressed in many tissues and cells to mediate various PGE₂ actions. The receptors couple to G_s to stimulate the cAMP second messenger signal transduction pathway. EP₂ receptors play important roles in mucosal protection, gastrointestinal secretion, and motility. The diverse effects of PGE₂ acting via EP₂ receptors make it an interesting drug target. Therefore, EP₂ subtype selective agonists, antagonists, and modulators have been identified with potential therapeutic applications.

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

WARNING This product is not for human or veterinary use.