A cell-based assay for studying modulators of efferocytosis.
Features
  • Study modulators of efferocytosis, apoptosis, pro-resolving mediators, and cross-presentation
  • Visualize effector (phagocytic) cells and bait (apoptotic) cells simultaneously
  • Contains CytoTell™ Blue and CSFE Dyes
  • Includes sufficient reagents to stain 5 x 107 effector cells and 2 x 108 bait cells
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Efferocytosis Assay Kit

Item No. 601770

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 ea

    $413

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    Product Description

    Efferocytosis is a specialized form of phagocytosis in which macrophages and other phagocytic cells clear dead and dying cells to promote homeostasis, embryonic development, regulation of the immune system and the resolution of inflammation.1 Efficient clearance of cells is essential for the removal of the nearly 1 million cells per second undergoing apoptosis in a human adult.2 Efferocytic removal of apoptotic cells before they become necrotic and release their contents can prevent an immune response to these non-pathogenic antigens.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Korns, D., Frasch, C., Fernandez-Boyanapalli, R., et al. Modulation of marcrophage efferocytosis in inflammation. Front. Immunol. 2(57), 1-10 (2011).

    2. Karaji, N., and Sattentau, Q.J. Efferocytosis of pathogen-infected cells. Front. Immunol. 8(1863), 1-10 (2017).

    Product Citations

    Sarkis, S., Gutowska, A., Rahman, M.A., et al. High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques. Nat. Commun. 16(1), 8470 (2025).

    Tanwar, V.S., Reddy, M.A., Dey, S., et al. Palmitic acid alters enhancers/super-enhancers near inflammatory and efferocytosis-associated genes in human monocytes. J. Lipid Res. 66(4), 100774 (2025).

    Yu, M., Dorsey, K.H., Halseth, T., et al. Enhancement of anti-inflammatory effects of synthetic high-density lipoproteins by incorporation of anionic lipids. Mol. Pharm. 20(11), 5454-5462 (2023).

    Nasir, N.J.M., Heemskerk, H., Jenkins, J., et al. Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle. Elife 12, e85633 (2023).

    Stamos, J.D., Rahman, M.A., Gorini, G., et al. Effect of passive administration of monoclonal antibodies recognizing simian immunodeficiency virus (SIV) V2 in CH59-Like coil/helical or β-sheet conformations on time of SIVmac251 acquisition. J. Virol. 97(4), e0186422 (2023).

    Lin, N., Shay, J.E.S., Xie, H., et al. Myeloid cell hypoxia-inducible factors promote resolution of inflammation in experimental colitis. Front. Immunol. 9(2565), (2018).

    Plastira, I., Bernhart, E., Goeritzer, M., et al. Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotyp. J. Neuroinflammation 14(1), 253 (2017).