A stable analog of PAF C-16
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Methylcarbamoyl PAF C-16

Item No. 60908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-hexadecyl-2-O-(N-methylcarbamoyl)-sn-glyceryl-3-phosphorylcholine
CAS Number
91575-58-5
Molecular Formula
C26H55N2O7P
Formula Weight
538.7
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 25 mg/ml
SMILES
CCCCCCCCCCCCCCCCOC[C@@H](OC(NC)=O)COP(OCC[N+](C)(C)C)([O-])=O
InChi Code
InChI=1S/C26H55N2O7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-32-23-25(35-26(29)27-2)24-34-36(30,31)33-22-20-28(3,4)5/h25H,6-24H2,1-5H3,(H-,27,29,30,31)/t25-/m1/s1
InChi Key
FNFHZBKBDFRYHS-RUZDIDTESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $333

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    10 mg

    $618

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    Product Description

    Methylcarbamoyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamoyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.2 Methylcarbamoyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hadváry, P., Cassal, J.M., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23, 57-64 (1983).

    2. Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. The Journal of Biological Chemisty 272(36), 22898-22904 (1997).