An inositol phosphate
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D-myo-Inositol-1,4,5-triphosphate (potassium salt)

Item No. 60960

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-myo-inositol-1,2,5-tris(dihydrogen phosphate), tripotassium salt
CAS Number
141611-11-2
Synonyms
  • Ins(1,4,5)-P3 (potassium salt)
  • 1,4,5-IP3 (potassium salt)
Molecular Formula
C6H12O15P3 • 3K
Formula Weight
534.4
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: >50 mg/ml
SMILES
O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O.[K+].[K+].[K+]
InChi Code
InChI=1S/C6H15O15P3.3K/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2+,3+,4?,5?,6?;;;/m1.../s1
InChi Key
MQMSEISCCNPXIL-FMCZHWOXSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $36

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    500 µg

    $81

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    1 mg

    $142

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    5 mg

    $609

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    Product Description

    D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate.1,2 It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Streb, H., Irvine, R.F., Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306(5938), 67-69 (1983).

    2. Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Jpn. J. Pharmacol. 74(2), 125-137 (1997).

    3. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu. Rev. Pharmacol. Toxicol. 36, 481-509 (1996).