A PLA2 substrate
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Arachidonoyl thio-PC

Item No. 62240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-hexadecyl-2-deoxy-2-thio-R-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glyceryl-3-phosphorylcholine
CAS Number
146797-82-2
Synonyms
  • 2-deoxy-2-thio Arachidonoyl PC
Molecular Formula
C44H82NO6PS
Formula Weight
784.2
Purity
≥98%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol containing 0.1% BHT
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlWater: 0.5 mg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(S[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COCCCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C44H82NO6PS/c1-6-8-10-12-14-16-18-20-22-23-24-25-27-29-31-33-35-37-44(46)53-43(42-51-52(47,48)50-40-38-45(3,4)5)41-49-39-36-34-32-30-28-26-21-19-17-15-13-11-9-7-2/h14,16,20,22,24-25,29,31,43H,6-13,15,17-19,21,23,26-28,30,32-42H2,1-5H3/b16-14
InChi Key
YDSCLGYBUIDZNF-WWBBCYQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $270

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    10 mg

    $513

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    25 mg

    $1,078

    Add
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    Product Description

    Arachidonoyl thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagents such as DTNB (Ellman’s reagent) and DTP to allow quantitation of PLA2 activity.1 Isozyme-specific cPLA2 activity can be measured by excluding or inhibiting sPLA2 and iPLA2 activities in the assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, L., and Dennis, E.A. Thio-based phospholipase assay. Methods Enzymol. 197, 65-75 (1991).