A substrate for some PLA2s
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10-Pyrene-PC

Item No. 62245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-O-hexadecanoyl-2-O-(10-(1-pyrenyl)decanoyl)-sn-glyceryl-3-phosphorylcholine
CAS Number
95864-17-8
Synonyms
  • 1-Palmitoyl-2-pyrenedecanoyl Phosphatidylcholine
Molecular Formula
C50H76NO8P
Formula Weight
850.1
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in chloroform
SMILES
O=C(CCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCC1=CC(C=CC2=CC=C3)=C(C2=C3C=C4)C4=C1)=O)COP(OCC[N+](C)(C)C)([O-])=O
InChi Code
InChI=1S/C50H76NO8P/c1-5-6-7-8-9-10-11-12-13-14-17-20-23-29-47(52)56-39-46(40-58-60(54,55)57-36-35-51(2,3)4)59-48(53)30-24-21-18-15-16-19-22-26-41-37-44-33-31-42-27-25-28-43-32-34-45(38-41)50(44)49(42)43/h25,27-28,31-34,37-38,46H,5-24,26,29-30,35-36,39-40H2,1-4H3/t46-/m1/s1
InChi Key
QHLZGRKUPPBYQM-YACUFSJGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $168

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    5 mg

    $753

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    10 mg

    $1,087

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    Product Description

    10-Pyrene-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH.1 Upon phospholipid hydrolysis, 10-pyrenyldecanoic acid is produced from 10-pyrene-PC. The monomeric 10-pyrenyldecanoic acid exhibits fluorescence (excitation 345 nm, emission 395 nm), allowing quantitation of phospholipase activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, M.F. Phospholipases: Structural and functional motifs for working at an interface. FASEB J. 10(10), 1159-1172 (1996).

    2. Lusa, S., Myllärniemi, M., Volmonen, K., et al. Degradation of pyrene-labelled phospholipids by lysosomal phospholipases in vitro. Dependence of degradation on the length and position of the labelled and unlabelled acyl chains. Biochem. J. 315, 947-952 (1996).