An analog of C8 ceramine
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Product Categories

Product Type

Biochemicals
Lipids
Sphingolipids

Research Area

Lipid Biochemistry
Sphingolipids

C8 Ceramine (d18:1/8:0)

Item No. 62545

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-octylsphingosine
CAS Number
170926-06-4
Synonyms
  • C8 Ceramine
  • Ceramine (d18:1/8:0)
Molecular Formula
C26H53NO2
Formula Weight
411.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >22 mg/ml (from C-8 Ceramide)DMSO: >20 mg/ml (from C-8 Ceramide)Ethanol: >33 mg/ml (from C-8 Ceramide)Ethanol:PBS(pH 7.2)(1:1): 0.5 mg/mlPBS pH 7.2: <50 µg/ml (from C-8 Ceramide)
SMILES
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NCCCCCCCC)CO
InChi Code
InChI=1S/C26H53NO2/c1-3-5-7-9-11-12-13-14-15-16-17-18-20-22-26(29)25(24-28)27-23-21-19-10-8-6-4-2/h20,22,25-29H,3-19,21,23-24H2,1-2H3/b22-20+/t25-,26+/m0/s1
InChi Key
CSRGRGSMEUKQSD-XQAXIDAFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    10 mg

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    Product Description

    C8 Ceramine is an analog of C8 ceramide (Item No. 62540) in which the carbonyl group of the ceramide is replaced by a methylene group. At a concentration of 10 µM, C8 ceramine induces maximal DNA fragmentation in U937 cells after 6 hours of incubation, compared to 12 hours for C8 ceramide.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karasavvas, N., Erukulla, R.K., Bittman, R., et al. Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis. Eur. J. Biochem. 236(2), 729-737 (1996).