A SPHK inhibitor
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N,N-Dimethylsphingosine (d18:1)

Item No. 62575

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-(dimethylamino)-4E-octadecene-1,3R-diol
CAS Number
119567-63-4
Molecular Formula
C20H41NO2
Formula Weight
327.6
Purity
≥98%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 25 mg/mlPBS pH 7.2: 1 mg/ml
SMILES
OC[C@H](N(C)C)[C@H](O)/C=C/CCCCCCCCCCCCC
InChi Code
InChI=1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChi Key
YRXOQXUDKDCXME-YIVRLKKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $61

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    10 mg

    $116

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    25 mg

    $242

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    50 mg

    $455

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    Product Description

    N,N-Dimethylsphingosine is a metabolite of sphingosine and an inhibitor of sphingosine kinase (SPHK) with Ki values of 3.1, 6.8, and 2.3 µM in U937, PC12, and Swiss 3T3 cell extracts, respectively.1,2 It is selective for SPHK over PKC in PC12 cells when used at a concentration of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yatomi, Y., Ruan, F., Megidish, T., et al. N,N-Dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35, 626-633 (1996).

    2. Edsall, L.C., Van Brocklyn, J.R., Cuvillier, O., et al. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37, 12892-12898 (1998).