Antagonizes DP receptor agonist effects
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Palmityl Trifluoromethyl Ketone

Item No. 62650

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,1-trifluoro-2-heptadecanone
CAS Number
141022-99-3
Synonyms
  • Pentadeca Trifluoromethyl Ketone
  • PTK
Molecular Formula
C17H31F3O
Formula Weight
308.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
basic PBS: freely solubleDMF: >50 mg/mlDMSO: >30 mg/mlEthanol: >50 mg/mlPBS pH 7.2: <50 µg/ml (from ATK)
SMILES
CCCCCCCCCCCCCCCC(=O)C(F)(F)F
InChi Code
InChI=1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
InChi Key
MAHYXYTYTLCTQD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $16

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    5 mg

    $50

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    10 mg

    $74

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    25 mg

    $139

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    Product Description

    PTK is an analog of palmitic acid in which the COOH group is replaced by trifluoromethyl ketone. In P388D1 cells, PTK inhibits iPLA2 activity with an IC50 value of 3.8 µM.1 A related compound, ATK is a less potent inhibitor of iPLA2 with an IC50 value of 15 µM.1 PTK also inhibits the activity of cPLA2 with an IC50 value almost identical to that of ATK.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ackermann, E.J., Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. The Journal of Biological Chemisty 270(1), 445-450 (1995).

    2. Conde-Frieboes, K., Reynolds, L.J., Lio, Y.C., et al. Activated ketones as inhibitors of intracellular Ca2+-dependent and Ca2+-independent phospholipase A2. J. Am. Chem. Soc. 118, 5519-5525 (1996).