A competitive, reversible inhibitor of sPLA2
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Thioetheramide-PC

Item No. 62750

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dideoxy-1-(S-hexadecyl)thio-2-(N-hexadecanoyl)amino-sn-glyceryl-3-phosphorylcholine
CAS Number
116457-99-9
Synonyms
  • 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
Molecular Formula
C40H83N2O5PS
Formula Weight
735.1
Purity
≥95%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
4.25 mM Triton X-100: SolubleEthanol: 10 mg/ml
SMILES
CCCCCCCCCCCCCCCC(N[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)CSCCCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C40H83N2O5PS/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-36-49-38-39(37-47-48(44,45)46-35-34-42(3,4)5)41-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h39H,6-38H2,1-5H3,(H-,41,43,44,45)/t39-/m0/s1
InChi Key
WLWWVTPUDQTUJU-KDXMTYKHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $77

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    10 mg

    $145

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    25 mg

    $339

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    Product Description

    Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).1,2 The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, L., Deems, R.A., Hajdu, J., et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. The Journal of Biological Chemisty 265, 2657-2664 (1990).

    2. Plesniak, L.A., Boegeman, S.C., Segelke, B.W., et al. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry 32, 5009-5016 (1993).