A competitive inhibitor of SAM-dependent methyltransferase
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S-Farnesyl Thioacetic Acid

Item No. 63260

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,7,11-trimethyl-2E,6E,10-dodecatrienyl)thioacetic acid
CAS Number
135784-48-4
Synonyms
  • FTA
Molecular Formula
C17H28O2S
Formula Weight
296.5
Purity
≥97%
Formulation
A 10 mg/ml solution in ethanol
SMILES
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSCC(O)=O
InChi Code
InChI=1S/C17H28O2S/c1-14(2)7-5-8-15(3)9-6-10-16(4)11-12-20-13-17(18)19/h7,9,11H,5-6,8,10,12-13H2,1-4H3,(H,18,19)/b15-9+,16-11+
InChi Key
GNWWFEVBHYESNK-XGGJEREUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $21

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    5 mg

    $86

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    10 mg

    $152

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    50 mg

    $655

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    Product Description

    S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can also inhibit methylation of both farnesylated and geranylgeranylated substrates.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochim. Biophys. Acta 1300, 5-16 (1996).

    2. Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett. 295(1-3), 189-194 (1991).

    3. Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem. J. 284(Pt 3), 835-840 (1992).