A synthetic substrate for SAM-dependent methyltransferase
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N-acetyl-S-farnesyl-L-Cysteine

Item No. 63270

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-S-(3,7,11-trimethyl-2E,6E,10-dodecatrienyl)-L-cysteine
CAS Number
135304-07-3
Synonyms
  • AFC
Molecular Formula
C20H33NO3S
Formula Weight
367.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 63 mg/mlDMF: 33 mg/mlDMSO: 20 mg/mlEthanol: 50 mg/ml
SMILES
CC(N([C@H](C(O)=O)CSC/C=C(CC/C=C(C)/CC/C=C(C)/C)\C)[H])=O
InChi Code
InChI=1S/C20H33NO3S/c1-15(2)8-6-9-16(3)10-7-11-17(4)12-13-25-14-19(20(23)24)21-18(5)22/h8,10,12,19H,6-7,9,11,13-14H2,1-5H3,(H,21,22)(H,23,24)/b16-10+,17-12+
InChi Key
XTURYZYJYQRJDO-JTCWOHKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $86

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    10 mg

    $153

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    25 mg

    $336

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    Product Description

    N-acetyl-S-farnesyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).1,2 Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Volker, C., Lane, P., Kwee, C., et al. A single activity carboxyl methylates both farnesyl and geranylgeranyl cysteine residues. FEBS Lett. 295(1-3), 189-194 (1991).

    2. Pérez-Sala, D., Gilbert, B.A., Tan, E.W., et al. Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates. Biochem. J. 284(Pt 3), 835-840 (1992).