A re-activator of the apoptotic function of mutant p53 proteins
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PRIMA-1

Item No. 63520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-bis(hydroxymethyl)-3-quinuclidinone
CAS Number
5608-24-2
Molecular Formula
C9H15NO3
Formula Weight
185.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 50 mg/ml
SMILES
OCC1(CO)N2CCC(CC2)C1=O
InChi Code
InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
InChi Key
RFBVBRVVOPAAFS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $21

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    5 mg

    $77

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    10 mg

    $116

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    50 mg

    $376

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    Cayman Chemical
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    Product Description

    PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.1 It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 8(3), 282-288 (2002).