A phosphatidylinositol
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PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)

Item No. 64910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(1,2R-dioctanoylphosphatidyl)inositol-4,5-bisphosphate, trisodium salt
Synonyms
  • DOPI-4,5-P2
  • Phosphatidylinositol-4,5-bisphosphate C-8
  • PIP2[4',5'](8:0/8:0)
  • PI(4,5)P2 (8:0/8:0)
Molecular Formula
C25H46O19P3 • 3Na
Formula Weight
812.5
Purity
≥97%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
CHCl3:CH3OH:H2O (3:2:1): 10 mg/mlPBS (pH 7.2): Freely soluble
SMILES
O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@@H](O)[C@H]1OP([O-])(OC[C@@H](COC(CCCCCCC)=O)OC(CCCCCCC)=O)=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C25H49O19P3.3Na/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36;;;/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36);;;/q;3*+1/p-3/t17-,2
InChi Key
WIFRKINRFJNHBB-JJMOSTGOSA-K
Side Chain Carbon Sum
16:0
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $68

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    500 µg

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    1 mg

    $476

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    5 mg

    $2,040

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    Product Description

    The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific research today.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lapetina, E.G., Billah, M.M., and Cuatrecasas, P. The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature 292(5821), 367-369 (1981).

    2. Majerus, P.W. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992).