An intermediate in the synthesis of latanoprost
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Latanoprost Lactone Diol

Item No. 70039

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aR,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-2H-cyclopenta[b]furan-2-one
CAS Number
145667-75-0
Molecular Formula
C18H24O4
Formula Weight
304.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): .3 mg/ml
λmax
208 nm
SMILES
O[C@@H]1C[C@H]2[C@H](CC(O2)=O)[C@H]1CC[C@@H](O)CCC3=CC=CC=C3
InChi Code
InChI=1S/C18H24O4/c19-13(7-6-12-4-2-1-3-5-12)8-9-14-15-10-18(21)22-17(15)11-16(14)20/h1-5,13-17,19-20H,6-11H2/t13-,14+,15+,16+,17-/m0/s1
InChi Key
CQVHXVLSHMRWEC-UTSKFRMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $125

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    50 mg

    $554

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    100 mg

    $984

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    Product Description

    Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactone diol is an intermediate in the synthesis of latanoprost. Latanoprost lactone diol can be converted to the free acid of latanoprost by reduction with DIBAL followed by Wittig reaction with commercially available reagents.

    WARNING This product is not for human or veterinary use.