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PAD4 Inhibitor Screening Assay Kit (Ammonia)

Item № 700560
product image
     96 wells $425.00 0.00

Pricing updated 2019-07-21. Prices are subject to change without notice.

  • Screen for inhibitors of PAD4
  • Assay 45 samples in duplicate
  • Plate-based fluorometric measurement (ex 405-415 nm, em 470-480 nm)
  • Orthogonal assay to Cayman’s PAD4 Inhibitor Screening Assay Kit (AMC) (Item No. 701320)
  • PADI4
  • PADI5
  • PDI5
  • Peptidylarginine Deiminase 4
  • Protein Arginine Deiminase 4

Protein Arginine Deiminase 4 (PAD4) is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting its enzymatic activity. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that generate an immune response resulting in production of autoantibodies that ultimately attack the host tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer’s disease, glaucoma, and cancer. Cayman’s PAD4 Inhibitor Screening Assay (Ammonia) provides a convenient, fluorescence-based method for screening human PAD4 inhibitors.

Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

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Technical Information
  • PADI4
  • PADI5
  • PDI5
  • Peptidylarginine Deiminase 4
  • Protein Arginine Deiminase 4

Warning - this product is not for human or veterinary use.

Shipping & Storage
Dry ice in continental US; may vary elsewhere
≥ 1 year
Downloads & Resources
Product Downloads

Download Kit Booklet

Download Safety Data Sheet (SDS)

Download free InChI Key generation software

Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Get Batch-Specific Data and Documents by Batch Number

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Citations

Tao, L., Xu, M., Dai, X., et al. Polypharmacological profiles underlying the antitumor property of Salvia miltiorrhiza root (Danshen) interfering with NOX-dependent neutriphil extracellular traps Oxid. Med. Cell. Longev. 4908328, (2018).

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