A selective HT2B receptor agonist
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BW 723C86

Item No. 70090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine, monohydrochloride
CAS Number
160521-72-2
Molecular Formula
C16H18N2OS • HCl
Formula Weight
322.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >55 mg/mlDMSO: >52 mg/mlEthanol: >6 mg/mlPBS pH 7.2: >160 µg/ml
λmax
224 nm
SMILES
NC(C)CC1=CN([H])C(C=C2)=C1C=C2OCC3=CC=CS3.Cl
InChi Code
InChI=1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H
InChi Key
PYJBJMIBANAOFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $20

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    5 mg

    $81

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    10 mg

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    50 mg

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    Product Description

    The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated via at least 6 major 5-HT receptor subtypes. Non-selective 5-HT receptor agonists, such as mCPP, induce many behavioral responses in rats, including increased anxiety, hypophagia, and hypoactivity. BW 723C86 is in fact anxiolytic, and its only other prominent behavioral effect is hyperphagia.1 This effect is likely due to the 10-fold selectivity of BW 723C86 for the HT2B receptor.2 Direct infusion of 1-3 µg of BW 723C86 into the cerebral ventricles of rats evokes maximal behavioral responses; the response was attenuated at both higher and lower doses.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kennett, G.A., Bright, F., Trail, B., et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br. J. Pharmacol. 117(7), 1443-1448 (1996).

    2. Kennett, G.A., Ainsworth, K., Trail, B., et al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology 36(2), 233-239 (1997).