A convenient method of screening human COX-1 inhibitors
Features
  • Screen for inhibitors of human COX-1
  • Directly measure prostaglandin production
  • Assay 16 samples in duplicate
  • Plate-based colorimetric measurement (405-420 nm)
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COX-1 (human) Inhibitor Screening Assay Kit

Item No. 701070

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cyclooxygenase 1
Assay Range
3.9-500 pg/ml
Sensitivity
10 pg/ml
Origin
Animal/Bovine, Animal/Eel, Animal/Rabbit
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    96 wells

    $480

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    Product Description

    The COX-1 (human) Inhibitor Screening Assay directly measures PGF2α by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2α.

    This assay includes recombinant human COX-1 and is an excellent tool for general COX-1 inhibitor screening. It will also help to eliminate false positive leads generated by less specific methods.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Mohamed, M.S., Mansour, Y.E., Amin, H.K., et al. Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives. J. Enzyme Inhib. Med. Chem. 33(1), 755-767 (2018).