A selective 15-hydroxy PGDH inhibitor
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CAY10397

Item No. 70130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
CAS Number
78028-01-0
Synonyms
  • CK47A
Molecular Formula
C17H16N2O5
Formula Weight
328.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 200 µg/mlDMF: 35 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
261, 370 nm
SMILES
OC1=C(CC(O)=O)C=C(N=NC2=CC=C(C(OCC)=O)C=C2)C=C1
InChi Code
InChI=1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22)
InChi Key
YYBSDOZYJSGLTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $279

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    10 mg

    $493

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    25 mg

    $1,077

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    Product Description

    Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 µM.1 CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berry, C.N., Hoult, J.R., Peers, S.H., et al. Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. Biochem. Pharmacol. 32(19), 2863-2871 (1983).

    Product Citations

    Johnsson, A.-K., Rönnberg, E., Fuchs, D., et al. COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1866(5), 158886 (2021).

    Lalier, L., Pedelaborde, F., Braud, C., et al. Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell. BMC Cancer 11, 153 (2011).